L-Glutathione 600mg
$85.00
Glutathione is a potent anti-oxidant and regulator of a number of biochemical processes. It is abundant in human tissues, but subject to decline with aging. Research shows that glutathione can help to reduce neurodegenerative disease, promote cartilage health, ward off age-related changes in the eye, improve immune function, and maintain more youthful skin. Overall, there is robust evidence that glutathione is a potent anti-aging compound with extensive immune and health benefits.
Description
L-Glutathione is a short peptide composed of just cysteine, glutamate, and glycine. It occurs naturally throughout the body and acts primarily as an antioxidant and as a supportive agent to a number of processes in the central nervous system. Glutathione is especially important in the detoxification processes of the liver and as a free-radical scavenger in the brain. There is ample evidence to suggest that loss of glutathione can contribute to neurodegenerative diseases like Parkinson’s disease as well as diseases of the eye like cataracts and diabetic retinopathy. Reduced glutathione levels are thought to be both a consequence of aging as well as a contributor to the aging process. Chronic disease also reduces glutathione levels.
Oral glutathione supplementation appears to be ineffective due to the breakdown of the peptide in the gastrointestinal system. Though much is made of oral supplementation with glutathione precursors like N-acetyl cysteine (NAC), research shows that glutathione levels tend to decrease with age due to a loss of production capacity (usually starting around middle age). This loss of production capacity, of course, limits the effectiveness of NAC and other precursors to generate glutathione. The best evidence indicates that glutathione is most effective when injected or inhaled via nasal preparations.
Molecular Formula: C10H17N3O6S
Molecular Weight: 307.33 g/mol
PubChem CID: 124886
CAS No: 170-18-8
Alternative Names: Glutathione, Isethion, GSH
L-Glutathione has long been recognized as one of the most important low-molecular weight antioxidants synthesized by cells of the body. By virtue of the sulfur contained in the cysteine component of GSH, it is able to remove potent free radicals, such as peroxides, nitrogen dioxide, HOCl, and a multitude of other toxins, from the body. It does this through a basic redox reaction, thus protecting cells, DNA, and extracellular matrix components from the damage done by free radicals. Glutathione not only neutralizes free radicals directly, but assists other antioxidants, such as vitamins C and E, in their roles as antioxidants[1].
Glutathione is found both inside cells and as a secreted substance in the extracellular matrix. It is found in very high levels in lung tissue, the brain, and the liver. It is synthesized in humans via a simple redox reaction as follows.
Glutathione is so important in the human body that deficiency has been associated with a wide range of diseases such as diabetes, HIV, cancer, and even tuberculosis. Research suggests that glutathione levels may be an important marker of disease severity and progression. Measuring glutathione may offer clinicians a more quantitative means of assessing prognosis and helping to determine the efficacy and timing of various interventions[2]. Despite understanding the role of glutathione in aging and disease, no routine means of measuring and assessing glutathione levels has been established. Researchers are now looking into how measuring this simple peptide could provide critical insight into everything from overall health to the efficacy of specific treatments in disease. In the near future, measuring glutathione levels may be as commonplace and useful as measuring things like blood pressure, cholesterol, and blood sugar levels.
